Disturbances of higher cerebral function

Peter J. Nestor and John R. Hodges

in Oxford Textbook of Medicine

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199204854
Published online November 2012 | e-ISBN: 9780199570973 | DOI:

Series: Oxford Textbooks

Disturbances of higher cerebral function

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Clinico-pathological and imaging studies indicate strong associations between particular disorders of cognition and focal disease in the brain, but not all focal lesions induce specific loss of higher functions. Neuropsychological research has deepened our understanding by suggesting organizational frameworks for human cognitive faculties.

The neocortex around the primary sensory and motor cortices is made up of unimodal association areas, which link to heteromodal association areas, with the linkage of topographical region to specific functional attribute becoming progressively less tightly defined. Other areas of the brain that interact with these association areas in a critical way for cognition include (1) limbic system—particularly in the domains of memory and emotion; (2) basal forebrain nuclei—important to the successful encoding of memory; (3) basal ganglia—relating to attention and speed of cognitive processing; (4) brainstem reticular formation—determining the level of arousal....

Chapter.  8566 words.  Illustrated.

Subjects: Neurology

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