Bisphosphonates for bone pain

Rebecca Wong

in Cancer-related Bone Pain

Published on behalf of Oxford University Press

ISBN: 9780199215737
Published online May 2011 | e-ISBN: 9780199606979 | DOI:

Series: Oxford Pain Management Library Opml P

Bisphosphonates for bone pain

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  • Radiation Oncology
  • Pain Medicine


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In the 1960s, Fleisch and Bisaz identified substances in the blood and urine that prevented the formation and dissolution of calcium phosphate crystals, which were later characterized as pyrophosphates (Fleisch and Bisaz, 1962). Recognizing their biophysical properties, Fleisch hypothesized that pyrophosphates were an important regulator of bone mineralization and demineralization, and potentially useful in preventing or treating abnormal calcification and excessive bone destruction (Fleisch, 1987). This chapter will discuss the data on bisphosphonates in the management of cancer-related bone pain.

Chapter.  3821 words.  Illustrated.

Subjects: Radiation Oncology ; Pain Medicine

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