Chapter

Ovarian ablation

Kellie L. Jones

in Endocrine Therapies in Breast Cancer

Published on behalf of Oxford University Press

Published in print November 2007 | ISBN: 9780199218141
Published online May 2011 | e-ISBN: 9780191739873 | DOI: https://dx.doi.org/10.1093/med/9780199218141.003.0002

Series: Oxford Oncology Library

Ovarian ablation

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Ovarian ablation can be achieved through oophorectomy, irradiation, or via medical ablation (chemo-therapy-induced or with the administration of luteinizing hormone releasing hormone (LHRH) agonists).

An oophorectomy is effective in reducing levels of oestrogen to a menopausal state, but this procedure is irreversible.

Radiation therapy to the ovaries can induce post-menopausal oestrogen levels; however this technique is slow to take effect and is not 100% effective.

LHRH agonist therapy can induce reversible ovarian suppression and is well tolerated.

Studies have reported that ovarian ablation/suppression reduces the recurrence and mortality rates in the treatment of early breast cancer.

Chapter.  5620 words. 

Subjects: Radiation Oncology

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