Chapter

Ovarian ablation

Kellie L. Jones

in Endocrine Therapies in Breast Cancer

Published on behalf of Oxford University Press

ISBN: 9780199218141
Published online May 2011 | e-ISBN: 9780199606993 | DOI: http://dx.doi.org/10.1093/med/9780199218141.003.0002

Series: Oxford Oncology Library

Ovarian ablation

Show Summary Details

Preview

• Ovarian ablation can be achieved through oophorectomy, irradiation, or via medical ablation (chemo-therapy-induced or with the administration of luteinizing hormone releasing hormone (LHRH) agonists). • An oophorectomy is effective in reducing levels of oestrogen to a menopausal state, but this procedure is irreversible. • Radiation therapy to the ovaries can induce post-menopausal oestrogen levels; however this technique is slow to take effect and is not 100% effective. • LHRH agonist therapy can induce reversible ovarian suppression and is well tolerated. • Studies have reported that ovarian ablation/suppression reduces the recurrence and mortality rates in the treatment of early breast cancer.

Chapter.  5625 words. 

Subjects: Clinical Oncology

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.