Ovarian ablation

Kellie L. Jones

in Endocrine Therapies in Breast Cancer

Published on behalf of Oxford University Press

ISBN: 9780199218141
Published online May 2011 | e-ISBN: 9780199606993 | DOI:

Series: Oxford Oncology Library

Ovarian ablation

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• Ovarian ablation can be achieved through oophorectomy, irradiation, or via medical ablation (chemo-therapy-induced or with the administration of luteinizing hormone releasing hormone (LHRH) agonists). • An oophorectomy is effective in reducing levels of oestrogen to a menopausal state, but this procedure is irreversible. • Radiation therapy to the ovaries can induce post-menopausal oestrogen levels; however this technique is slow to take effect and is not 100% effective. • LHRH agonist therapy can induce reversible ovarian suppression and is well tolerated. • Studies have reported that ovarian ablation/suppression reduces the recurrence and mortality rates in the treatment of early breast cancer.

Chapter.  5625 words. 

Subjects: Clinical Oncology

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