Aromatase inhibitors in early and advanced disease

Laura Boehnke Michaud

in Endocrine Therapies in Breast Cancer

Published on behalf of Oxford University Press

ISBN: 9780199218141
Published online May 2011 | e-ISBN: 9780199606993 | DOI:

Series: Oxford Oncology Library

Aromatase inhibitors in early and advanced disease

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• Aromatase inhibitors are effective endocrine therapies for postmenopausal women with metastatic breast cancer. • Compared with tamoxifen, the new generation aromatase inhibitors are generally better tolerated with less associated morbidity. • For early stage breast cancer, new generation aromatase inhibitors should be incorporated into adjuvant therapy for hormonally sensitive, postmenopausal breast cancer. • The optimal method to incorporate the aromatase inhibitors into the adjuvant treatment of early stage breast cancer is unknown. • The use of these agents in premenopausal women is contraindicated unless in the context of a clinical trial in combination with ovarian ablation or suppression.

Chapter.  5383 words.  Illustrated.

Subjects: Radiation Oncology

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