Chapter

Progestins and androgens

Janet L. Espirito

in Endocrine Therapies in Breast Cancer

Published on behalf of Oxford University Press

ISBN: 9780199218141
Published online May 2011 | e-ISBN: 9780199606993 | DOI: http://dx.doi.org/10.1093/med/9780199218141.003.0006

Series: Oxford Oncology Library

Progestins and androgens

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• Progestins and androgens are synthetic derivatives of the natural hormones progesterone and testosterone, used in the treatment of metastatic breast cancer. • Although the mechanisms for how they work are unknown, these are effective therapies for patients with hormone responsive disease. • The most widely used progestins are medroxypro-gesterone acetate and megestrol acetate. Fluoxy-mesterone is the androgen most commonly used. • Based on tolerability and efficacy, progestins and androgens have moved sequentially down the line of treatment following progression on aromatase inhibitors and antioestrogens. • Although these are older compounds, they are generally well tolerated and still have a role in therapy.

Chapter.  2669 words.  Illustrated.

Subjects: Clinical Oncology

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