Chapter

Combined endocrine and chemotherapy in breast cancer

Ishmael Jaiyesimi, Shannon Wills, Richard Zekman, Dave Decker and Aman U. Buzdar

in Endocrine Therapies in Breast Cancer

Published on behalf of Oxford University Press

ISBN: 9780199218141
Published online May 2011 | e-ISBN: 9780199606993 | DOI: http://dx.doi.org/10.1093/med/9780199218141.003.0007

Series: Oxford Oncology Library

Combined endocrine and chemotherapy in breast cancer

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• Combining adjuvant endocrine therapy with tamoxifen, and chemotherapy is superior than either modality alone. • Sequentially administered antiestrogen therapy is better than concomitant administration with chemotherapy. • Efficacy of aromatase inhibitors is not altered by prior adjuvant chemotherapy. • The role of ovarian ablation or suppression in premenopausal women following adjuvant chemotherapy remains an area of ongoing research. • In metastatic disease, endocrine therapies and chemotherapies should be sequentially utilized - concomitant use offers no advantage.

Chapter.  5912 words. 

Subjects: Clinical Oncology

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