Andrew Dickman and Roger Knaggs

in Chronic Pain

Published on behalf of Oxford University Press

ISBN: 9780199230280
Published online May 2011 | e-ISBN: 9780199607020 | DOI:

Series: Oxford Pain Management Library


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• Tramadol has a complex mechanism of action involving both serotonin/noradrenaline re-uptake inhibition and opioid activity • An understanding of its pharmacology is essential for successful treatment • Its opioid effect requires hepatic activation via cytochrome CYP2D6 • Genetic variation and drug interactions can alter both the analgesic and adverse effect profiles.

Chapter.  1288 words.  Illustrated.

Subjects: Clinical Medicine ; Pain Medicine

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