The history of evidence-based medicine

Edited by James Harrison, Kunal Kulkarni, Mohamed Baguneid and Bernard Prendergast

in Oxford Handbook of Key Clinical Evidence

Published on behalf of Oxford University Press

Published in print November 2009 | ISBN: 9780199234073
Published online August 2010 | e-ISBN: 9780199598830 | DOI:

Series: Oxford Medical Handbooks

The history of evidence-based medicine

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The nature of evidence - Making comparisons - The first prospective controlled trial - The enlightenment - The importance of case studies - The 19th century - Statistical developments - Of placebos and the mind in 18th and 19th century healing - Problems of design: the clinical trial in the 19th and 20th centuries - The rise of the randomised controlled trial - Ethics and experimentation - Chronology

Chapter.  9562 words. 

Subjects: Medical Statistics and Methodology

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