Anaesthetic pharmacology in the elderly

Chris Dodds, Chandra M. Kumar and Frédérique Servin

in Anaesthesia for the Elderly Patient

Published on behalf of Oxford University Press

Published in print October 2007 | ISBN: 9780199234622
Published online May 2011 | e-ISBN: 9780199607082 | DOI:

Series: Oxford Anaesthesia Library

Anaesthetic pharmacology in the elderly

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Initial distribution of drugs is often impaired.

Protein binding is less efficient.

Excretion of water-soluble drugs or metabolites is reduced.

Clearance of highly extracted drugs decreases with liver blood flow.

Inter-individual variability increases with age.

Titration to effect is mandatory.

Always favour the shortest acting and most titrable drugs.

Chapter.  4486 words.  Illustrated.

Subjects: Anaesthetics

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