The historical basis of restless legs syndrome

K. Ray Chaudhuri and Sharon Muzerengi

in Restless Legs Syndrome

Published on behalf of Oxford University Press

ISBN: 9780199234882
Published online May 2011 | e-ISBN: 9780199607105 | DOI:

Series: Oxford Neurology Library

The historical basis of restless legs syndrome

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• Restless legs syndrome (RLS) was first described by Thomas Willis in the seventeenth century although there are references to this condition in ancient Chinese literature. • The term restless legs syndrome was first used by Karl Ekbom in 1945. • The diagnostic criteria for RLS was established in 1995 by the IRLSSG and further modified in 2003. • The genetic basis of RLS has also been extensively investigated in recent years and linkages to several chromosomes have been found. • Most recently a specific association between a sequence variant in chromosome 6p and periodic limb movements in sleep in distinct Icelandic and American cohorts of subjects with RLS and their families, as well as controls has been an exciting development. • Two additional single-nucleotide polymorphisms (SNPs) in German and Canadian cohorts with RLS have also been simultaneously reported.

Chapter.  2044 words.  Illustrated.

Subjects: Neurology

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