Edited by David Rye, Luigi Ferini-Strambi and K. Ray Chaudhuri

in Restless Legs Syndrome

Published on behalf of Oxford University Press

ISBN: 9780199234882
Published online May 2011 | e-ISBN: 9780199607105 | DOI:

Series: Oxford Neurology Library


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• RLS is remarkably common; it is more often encountered in women and especially in those of Northern European descent, and may be either idiopathic or secondary to several medical conditions. • Idiopathic RLS has a strong genetic component. • RLS follows a complex familial inheritance pattern rather than a simple Mendelian inheritance one typical of a single gene effect. • Recent genome-wide association studies have identified a single gene variant within the BTBD9 gene on the short arm of chromosome 6 as conferring considerable susceptibility to RLS and periodic leg movements in sleep. • Three additional gene loci conferring nominal to moderate risk have also been identified. • The most well-established ‘causes’ of secondary RLS are iron deficiency (even in the absence of anaemia), pregnancy, and end-stage renal disease. • Less often encountered causes of RLS include myelopathy and gastric bypass surgery, while associations have been noted with diabetes, neuropathy, and arthritic conditions.

Chapter.  2343 words. 

Subjects: Neurology

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