Future directions

David Rye and K. Ray Chaudhuri

in Restless Legs Syndrome

Published on behalf of Oxford University Press

ISBN: 9780199234882
Published online May 2011 | e-ISBN: 9780199607105 | DOI:

Series: Oxford Neurology Library

Future directions

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• Recent genetic research has identified four common gene variants that confer substantial risk of developing RLS. • Knowledge of cell biology of identified genes will help unravel the pathophysiology of RLS. • Pharmacogenomic studies will be possible and are likely to provide novel insights into the origins of unresponsiveness to dopaminergic treatment and possibly augmentation. • Epidemiological studies will further elaborate upon the negative impact of RLS on sleep, daytime functioning, fatigue, mood, and affect and will clarify whether RLS/PLMs indeed negatively impact cardiovascular health. • Several new drugs, some with non-oral mode of delivery or unique non-dopaminergic mechanisms of action, are in the development stage for the treatment of RLS.

Chapter.  1771 words. 

Subjects: Neurology

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