Neuroendocrine (carcinoid) tumours and the carcinoid syndrome

Rajaventhan Srirajaskanthan, Martyn E. Caplin and Humphrey Hodgson

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

Published in print July 2011 | ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI:

Series: Oxford Textbooks

Neuroendocrine (carcinoid) tumours and the carcinoid syndrome

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Neuroendocrine tumours (NETs) are derived from cells of the diffuse neuroendocrine system, which are present in organs throughout the body. Originally, Pearse proposed that tumours develop from migration of cells from the neural crest; however, it is now thought that the tumour cells are derived from multipotent stem cells (1).

The term ‘karzinoide’ (meaning carcinoma like) was initially introduced by Siegfried Oberndorfer in 1907 (2). The term carcinoid tumour has historically been used; however, with advances in the understanding of the tumour biology, and the recent WHO classification, the term NET or endocrine tumour is considered more appropriate, and more details are given in the historical introduction in Chapter 6.1.

Chapter.  5473 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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