Christos Toumpanakis and Martyn Caplin

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

Published in print July 2011 | ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI:

Series: Oxford Textbooks


More Like This

Show all results sharing this subject:

  • Endocrinology and Diabetes


Show Summary Details


Gastrin is a gastrointestinal hormone, produced predominantly by the G cells of the gastric antrum and duodenum, although small amounts of gastrin have been isolated in the pituitary and some vagal nerve fibres. The biologically active forms of gastrin include carboxy-amidated gastrin-17 and carboxy-amidated gastrin-34, which bind mainly to the cholecystokinin (CCK)-2 receptor. The main role of amidated gastrin is the stimulation of gastric acid secretion by regulation of histamine release from the gastric enterochromaffin-like (ECL) cells, while it may also have a trophic effect on gastric mucosa. There is evidence that the precursor forms of gastrin, such as progastrin and glycine-extended gastrin, are also of biological importance, binding to a separate CCK-C receptor. These precursor may induce cellular and tumour growth and they are implicated in several cancers, such as colon and pancreatic adenocarcinomas.

Gastrinomas represent a group of functional pancreatic neuroendocrine tumours, characterized by autonomous release of gastrin by the tumour cells, which results in symptoms not only due to the tumour growth per se, but also to gastric acid hypersecretion.

In 1955, at the annual meeting of American Surgical Association, Robert M. Zollinger and Edwin H. Ellison presented a study entitled Primary Peptic Ulcerations of the Jejunum Associated with Islet Cell Tumour of the Pancreas. They proposed a new clinical syndrome of: (1) ulceration in unusual locations in the upper gastrointestinal tract or recurrent ulcerations; (2) gastric acid hyperseretion; and (3) non-β‎ islet cell tumours of the pancreas. However, the potent gastric secretagogue for the Zollinger–Ellison syndrome was not identified until 1960, when Rodney Gregory and Hilda Tracy of the University of Liverpool discovered that the extract from the pancreas of a patient with Zollinger–Ellison syndrome was the hormone gastrin. Thus, these pancreatic tumours were termed ‘gastrinomas’.

Chapter.  3953 words.  Illustrated.

Subjects: Endocrinology and Diabetes

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.