Chapter

Insulinoma and hypoglycaemia

Puja Mehta and Jeannie F. Todd

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI: http://dx.doi.org/10.1093/med/9780199235292.003.0643

Series: Oxford Textbooks

Insulinoma and hypoglycaemia

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Hypoglycaemia is a clinical syndrome with diverse aetiology. Insulinomas, although rare, are the most common functioning pancreatic islet cell tumour and may be part of the multiple endocrine neoplasia type 1 (MEN 1) syndrome. Patients present with symptoms of neuroglycopenia and a catecholamine response. Diagnosis is confirmed by evidence of endogenous hyperinsulinaemic hypoglycaemia. Tumours are localized by ultrasonography, CT and/or intra-arterial calcium stimulation with venous sampling. Most tumours are benign and solitary, making surgical cure possible with complete resection. Medical options, including diazoxide or octreotide, are available for multifocal tumours.

Chapter.  4510 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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