Chapter

The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease

Markku Seppälä and Linda C. Giudice

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI: http://dx.doi.org/10.1093/med/9780199235292.003.0892

Series: Oxford Textbooks

The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease

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In biological terms, human life is a continuum in which male and female gametes fuse in fertilization (conception) to form an embryo. Usually fertilization takes place in the distal part of fallopian tube where the embryo remains 2–3 days, dividing at 12–15 h intervals. On day 3 the embryo has 8 cells, on day 4 a morula stage has been reached, and on day 5 the embryo forms a blastocyst and enters the uterus. The embryo hatches before it implants in the endometrium, most implantations (86%) occurring between day LH +8 and day LH +11 (1). The most reliable clinical sign of implantation is secretion of human chorionic gonadotropin (hCG) from the embryonic trophoblast into maternal serum and urine.

Chapter.  12942 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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