Treatment of hypothyroidism

Anthony Toft

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

Published in print July 2011 | ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI:

Series: Oxford Textbooks

Treatment of hypothyroidism

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Treatment of primary hypothyroidism is usually both gratifying and simple and, in most cases, lifelong. Thyroxine, as l-thyroxine sodium, is the therapy of choice and is available in the UK as tablets of 25, 50, and 100 μ‎g. A greater variety of tablet strength is marketed in other parts of Europe and North America. Thyroxine has a half-life of some 7 days and should be given as a single daily dose which improves compliance. Thyroxine, taken at bedtime, is associated with higher thyroid hormone concentrations and lower thyroid-stimulating hormone (TSH) concentrations compared to the same dose taken in the morning, probably due to greater gastrointestinal uptake of thyroxine during the night (1). Omitting the occasional tablet is of no consequence and those who forget to take their medication, e.g. on vacation, will experience little in the way of symptoms for the first 2 weeks.

Chapter.  3986 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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