Chapter

Treatment of hypothyroidism

Anthony Toft

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI: http://dx.doi.org/10.1093/med/9780199235292.003.3293

Series: Oxford Textbooks

Treatment of hypothyroidism

Show Summary Details

Preview

Treatment of primary hypothyroidism is usually both gratifying and simple and, in most cases, lifelong. Thyroxine, as l-thyroxine sodium, is the therapy of choice and is available in the UK as tablets of 25, 50, and 100 μg. A greater variety of tablet strength is marketed in other parts of Europe and North America. Thyroxine has a half-life of some 7 days and should be given as a single daily dose which improves compliance. Thyroxine, taken at bedtime, is associated with higher thyroid hormone concentrations and lower thyroid-stimulating hormone (TSH) concentrations compared to the same dose taken in the morning, probably due to greater gastrointestinal uptake of thyroxine during the night (1). Omitting the occasional tablet is of no consequence and those who forget to take their medication, e.g. on vacation, will experience little in the way of symptoms for the first 2 weeks.

Chapter.  3929 words.  Illustrated.

Subjects: Endocrinology and Diabetes

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.