Premature sexual maturation

Jean-Claude Carel and Juliane Léger

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI:

Series: Oxford Textbooks

Premature sexual maturation

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Premature sexual maturation is a frequent cause for referral in paediatric endocrinology. Although clinical evaluation will suffice to reassure the patient and family in a majority of cases, premature sexual maturation can reveal severe conditions and need a thorough evaluation to identify its cause and potential for progression, in order to propose an appropriate treatment (1). Although the use of long-acting GnRH agonists has revolutionized the treatment of central precocious puberty, questions remain regarding their optimal use (2). One of the main ongoing controversial issues in the area is the definition of normal pubertal development and there is a need for longitudinal assessments of normally developing children in the various areas of the world and of a better understanding of the factors affecting normal pubertal development to improve the recognition and proper management of premature sexual maturation.

Chapter.  6737 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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