Chapter

Late effects of cancer treatment

Andrew A. Toogood

in Oxford Textbook of Endocrinology and Diabetes

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199235292
Published online July 2011 | e-ISBN: 9780199608232 | DOI: http://dx.doi.org/10.1093/med/9780199235292.003.7133

Series: Oxford Textbooks

Late effects of cancer treatment

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In the last 40 years there has been a dramatic improvement in the treatment of malignant disease, particularly during childhood. The multidisciplinary approach to patient management utilizing various combinations of chemotherapeutic agents and, when appropriate, surgery, and radiotherapy has resulted in a rise in the overall survival rate from childhood cancer from 23% in the 1960s to 75% today. Acute lymphoblastic leukaemia (ALL) is cured in 81% of cases and for Hodgkin’s lymphoma and germ cell tumours cure is now achieved in excess of 90% of cases. (Fig. 7.4.1) It has been estimated that 1:715 young adults is a survivor of childhood cancer. The success seen in paediatric oncology is now being mirrored in adult oncology, particularly amongst younger adults; it is estimated that 2 million adults in the United Kingdom have been treated for and survived cancer.

Chapter.  11146 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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