Blockade of the renin–angiotensin–aldosterone system

Steven M. Shaw, John E. Macdonald and Simon G. Williams

in Chronic Heart Failure

Published on behalf of Oxford University Press

ISBN: 9780199542338
Published online May 2011 | e-ISBN: 9780199607174 | DOI:

Series: Oxford Cardiology Library

Blockade of the renin–angiotensin–aldosterone system

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• Blockade of the renin–angiotensin–aldosterone system is a cornerstone of treatment of patients with chronic heart failure (CHF). • The use of angiotensin-converting enzyme (ACE) inhibitors in patients with CHF improves quality of life and prognosis across all stages of the disorder. • The angiotensin receptor blockers are effective substitutes for ACE inhibitors. • The combination of ACE inhibitors and angiotensin-receptor blockers is effective in reducing mortality and morbidity in patients with CHF. • Spironolactone an aldosterone antagonist is effective in patients with more advanced heart failure; evidence in less severely symptomatic heart failure is awaited.

Chapter.  2113 words.  Illustrated.

Subjects: Cardiovascular Medicine

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