Chapter

Role of HPV in cervical carcinogenesis

Sally Roberts and Lawrence S Young

in Vaccines for the Prevention of Cervical Cancer

Published on behalf of Oxford University Press

ISBN: 9780199543458
Published online May 2011 | e-ISBN: 9780199607181 | DOI: http://dx.doi.org/10.1093/med/9780199543458.003.0003

Series: Oxford Oncology Library

Role of HPV in cervical carcinogenesis

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• Infection of squamous epithelia by specific human papilloma virus (HPV) types contributes to the development of cervical cancer; HPV 16 and HPV 18 are the most common oncogenic types present in cervical carcinomas. • The E6 and E7 oncoproteins, by dysregulating host cell cycle control and abrogating the host cell ’ s anti-proliferative response, promote the proliferation and survival of HPV infected cells. • Persistent expression of E6 and E7 oncoproteins allow the accumulation of genetic mutations that can lead to cellular immortalization and finally malignant conversion. • Integration of the HPV genome into the host chromosome, a common event in high-grade CIN and cervical carcinomas, up-regulates expression of E6 and E7 oncoproteins. • Cervical cancer is a late and rare complication of a persistent HPV infection and is the end result of a chain of events that can take many years to unfold—infection with HPV is necessary but not a sufficient cause of cervical cancer.

Chapter.  2885 words.  Illustrated.

Subjects: Medical Oncology

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