Chapter

The role of HPV testing in cervical screening

Margaret E Cruickshank

in Vaccines for the Prevention of Cervical Cancer

Published on behalf of Oxford University Press

ISBN: 9780199543458
Published online May 2011 | e-ISBN: 9780199607181 | DOI: http://dx.doi.org/10.1093/med/9780199543458.003.0005

Series: Oxford Oncology Library

The role of HPV testing in cervical screening

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• The knowledge that high-risk human papilloma virus (HPV) infection is necessary to develop cervical cancer has prompted the exploration of its utility in cervical screening. • HPV testing could be for triage of low-grade smears to improve the sensitivity of cytology alone, and select women at most risk who require colposcopy. • The sensitivity and specificity of HPV testing relate to the threshold of the test, and the underlying prevalence of cervical intraepithelial neoplasia (CIN) in the tested population. • The role of HPV testing in primary screening holds promise because of high sensitivity, but its lack of specificity will need to be addressed before it could be recommended to replace cytology as an initial screen. • HPV testing has been shown to detect residual disease following treatment of CIN earlier than cytology. Its use as a test of cure will allow earlier return to routine recall for most women.

Chapter.  2100 words. 

Subjects: Medical Oncology

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