Chapter

Natural immune control of HPV infection

Peter L Stern

in Vaccines for the Prevention of Cervical Cancer

Published on behalf of Oxford University Press

ISBN: 9780199543458
Published online May 2011 | e-ISBN: 9780199607181 | DOI: http://dx.doi.org/10.1093/med/9780199543458.003.0006

Series: Oxford Oncology Library

Natural immune control of HPV infection

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• Most human papilloma virus (HPV) infections in the cervix are naturally controlled. Initially this utilizes the innate immune response. • Innate immunity is mediated by cytokines such as interferon, produced by epithelial cells and antigen-presenting cells (APCs) or by lytic cells such as natural killer cells and macrophages which also produce cytokines. • APCs (e.g. dendritic cells) sense the local environment and transfer information about the HPV infection to the local lymph node to activate the adaptive immune response. • Optimally, a balance of T helper cell 1 and 2 types of response facilitates the development of both HPV-specific cytotoxic T cells (CTLs) and support for production of virus neutralizing antibodies by B cells. • Adaptive immunity provides the specificity of the immune weapons, their expansion, and provision of immunological memory. • Long-term control depends on memory B and T cells to provide a rapid delivery of cell-mediated immunity or neutralizing antibodies to halt any new virus infection at an early stage.

Chapter.  2855 words.  Illustrated.

Subjects: Medical Oncology

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