Chapter

Lipids, lipoproteins, and atherogenesis

Joanna Gouni-Berthold and Wilhelm Krone

in Hyperlipidaemia

Published on behalf of Oxford University Press

Published in print February 2012 | ISBN: 9780199543502
Published online October 2011 | e-ISBN: 9780191740084 | DOI: http://dx.doi.org/10.1093/med/9780199543502.003.0002

Series: Oxford Cardiology Library

Lipids, lipoproteins, and atherogenesis

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Lipids and lipoproteins have a central role in the pathogenesis of atherosclerosis.

The concentration of low-density lipoprotein (LDL) is strongly and directly related to risk of atherosclerosis whereas high-density lipoprotein (HDL) is inversly related, low HDL being an independent risk factor.

The role of plasma triglycerides is less well defined.

The ratio of apolipoprotein B (the major apolipoprotein of LDL) to apolipoprotein A-1 (the major apolipoprotein of HDL) is emerging as the best predictor of atherosclerotic risk.

Chapter.  5127 words. 

Subjects: Cardiovascular Medicine

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