Chapter

Pharmacological therapy: statins

Edited by D. John Betteridge

in Hyperlipidaemia

Published on behalf of Oxford University Press

Published in print February 2012 | ISBN: 9780199543502
Published online October 2011 | e-ISBN: 9780191740084 | DOI: http://dx.doi.org/10.1093/med/9780199543502.003.0007

Series: Oxford Cardiology Library

Pharmacological therapy: statins

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Statins are potent, competitive inhibitors of the rate-determining step in cholesterol synthesis which leads to up-regulation of hepatic LDL-receptor activity and decrease in plasma LDL.

There is a huge database of information from RCTS in both primary and secondary CVD prevention and in a wide range of patient groups on which to base therapy.

Statins are the most potent agents for reducing LDL and are first-line therapy for the great majority of patients.

Statins are safe and well tolerated, and myositis and abnormal liver function are exceedingly rare.

Chapter.  3910 words. 

Subjects: Cardiovascular Medicine ; Pharmacology

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