Chapter

Recent lipid-lowering trials in perspective: implications for therapy

Edited by D. John Betteridge

in Hyperlipidaemia

Published on behalf of Oxford University Press

ISBN: 9780199543502
Published online October 2011 | e-ISBN: 9780199607204 | DOI: http://dx.doi.org/10.1093/med/9780199543502.003.0010

Series: Oxford Cardiology Library

Recent lipid-lowering trials in perspective: implications for therapy

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• Despite the clinical benefits of statin therapy in primary and secondary cardiovascular disease (CVD) prevention trials, considerable residual risk persists. • Meta-analysis of major randomized controlled trials (RCTs) suggests that greater low-density lipoprotein (LDL)-lowering is associated with greater reduction in events. • Recent RCTs in stable coronary disease and in acute coronary syndrome have demonstrated greater benefit with more intensive LDL-lowering. • The results of these trials have changed LDL goals of therapy for those at highest risk.

Chapter.  3385 words.  Illustrated.

Subjects: Cardiovascular Medicine

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