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• Cholesterol and low-density lipoprotein (LDL)-cholesterol are causal factors for atheromatous cardiovascular disease (CVD), and moderate and higher levels are a near obligate for disease development.
• Statin drugs have overwhelming evidence of benefit at low side effect risk.
• Estimation of an individual's CVD risk is required from a number of factors, and CVD prevention requires attention to all abnormal modifiable factors in individuals at higher risk.
• Identifying, counselling, and appropriate treatment of individuals at high CVD risk is a current challenge for health care professionals.
• Guidelines have been produced to help, and Government has provided levers to encourage their application.
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