Chapter

Systems biology for elucidation of the effect of light on the circadian clocks

Hideki Ukai and Hiroki R. Ueda

in Seasonal Affective Disorder

Second edition

Published on behalf of Oxford University Press

Published in print October 2009 | ISBN: 9780199544288
Published online February 2013 | e-ISBN: 9780191754593 | DOI: http://dx.doi.org/10.1093/med/9780199544288.003.0003
Systems biology for elucidation of the effect of light on the circadian clocks

Show Summary Details

Preview

Systems biology is a natural extension of molecular biology, and can be defined as “biology after identification of key gene(s)” for obtaining an understanding of the design principle of a biological system. To elucidate the logic of a complex and dynamic biological system, quantitative perturbation of cellular states and quantitative measurement of its responses are indispensable. In this chapter, we describe in detail our systems-biological approaches, including quantitative photo-perturbation and high-resolution measurement, for elucidation of the effect of light on the circadian clock. By using these approaches, we have succeeded in analyzing the entrainment of the circadian clock system in individual cultured cells via artificial light-sensing mechanisms, and elucidated one of the longstanding and unsolved biological phenomena, known as the singularity behavior of circadian clocks. We also describe other unsolved system-level questions on the effects of light on circadian clocks.

Chapter.  4616 words.  Illustrated.

Subjects: Psychiatry

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.