Chapter

An Introduction to Cardioprotection

Edited by Derek Hausenloy and Derek Yellon

in Cardioprotection

Published on behalf of Oxford University Press

ISBN: 9780199544769
Published online May 2011 | e-ISBN: 9780199607228 | DOI: http://dx.doi.org/10.1093/med/9780199544769.003.0001

Series: Oxford Cardiology Library

An Introduction to Cardioprotection

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• In its broadest sense, the term ‘cardioprotection’ encompasses ‘all mechanisms and means that contribute to the preservation of the heart by reducing or even preventing myocardial damage’ • However, for the purposes of this book, the term ‘cardioprotection’ will refer to the endogenous mechanisms and therapeutic strategies that reduce or prevent myocardial damage induced by acute ischaemia-reperfusion injury • In this context, cardioprotection begins with the primary prevention of coronary heart disease and includes the reduction of myocardial injury sustained during coronary artery bypass graft surgery, and an acute myocardial infarction, conditions with considerable morbidity and mortality • An understanding of the pathophysiology of acute myocardial ischaemia-reperfusion injury is essential when designing new cardioprotective strategies • Several methods exist for both quantifying myocardial damage induced by acute ischaemia-reperfusion injury and for assessing myocardial salvage following the application of cardioprotective strategies • Importantly, novel cardioprotective strategies must be capable of preventing and reducing myocardial damage over and above that provided by current optimal therapy.

Chapter.  2759 words.  Illustrated.

Subjects: Cardiovascular Medicine

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