Primary Prevention of Coronary Heart Disease

Richard Hobbs

in Cardioprotection

Published on behalf of Oxford University Press

Published in print August 2009 | ISBN: 9780199544769
Published online May 2011 | e-ISBN: 9780191740107 | DOI:

Series: Oxford Cardiology Library

Primary Prevention of Coronary Heart Disease

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  • Cardiovascular Medicine


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Coronary heart disease (CHD) is the leading cause of death and disability in the world

The evidence base for the causes of CHD and for the interventions which reduce CHD risk is huge

Since CHD is multi-factorial, risk factors tend to co-exist in many patients, and are multiplicative in their influence on overall risk, making identifying people at highest risk clinically difficult

CHD risk scores have been developed, based on observed CHD rates amongst well-phenotyped patient cohorts followed up over years. These express absolute risk over a defined period and are the most practical method for determining which people have the most to gain from treatment interventions

Evidence-based interventions include smoking cessation, lifestyle modification in terms of diet and exercise, anti-hypertensives for elevated blood pressure, and ‘statins’ for hyperlipidaemia

Clinical guidelines for CHD prevention provide recommendations on specific targets for blood pressure and lipid-lowering therapy.

Chapter.  3958 words.  Illustrated.

Subjects: Cardiovascular Medicine

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