Coronary No-Reflow and Microvascular Obstruction

Edited by Derek Hausenloy and Derek Yellon

in Cardioprotection

Published on behalf of Oxford University Press

Published in print August 2009 | ISBN: 9780199544769
Published online May 2011 | e-ISBN: 9780191740107 | DOI:

Series: Oxford Cardiology Library

Coronary No-Reflow and Microvascular Obstruction

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Following an AMI, the restoration of TIMI III coronary blood flow using thrombolytic therapy or primary percutaneous coronary intervention does not guarantee actual myocardial perfusion

In 40–60% of reperfused AMI cases, myocardial perfusion is impeded at the level of the capillaries due to microvascular obstruction (MVO)- a phenomenon termed coronary no-reflow

The presence of coronary no-reflow can be detected as impaired myocardial perfusion using non-invasive imaging modalities such as nuclear myocardial perfusion scanning, myocardial contrast echocardiography or contrast-enhanced cardiac magnetic resonance imaging

The presence of microvascular obstruction post-AMI is associated with a larger infarct size, impaired LV ejection fraction, adverse LV remodelling and poorer clinical outcomes

Current treatment strategies include; vasodilator therapy such as adenosine, calcium-channel blockers, and nitrates; distal protection to prevent microemboli; and glycoprotein IIb/IIIa inhibitors

Novel treatment strategies are required to prevent and treat coronary no-reflow, thereby improving myocardial perfusion, reducing myocardial infarct size, preserving LV ejection fraction, preventing LV remodeling and improving clinical outcomes.

Chapter.  3459 words.  Illustrated.

Subjects: Cardiovascular Medicine

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