Endogenous Mechanisms of Cardioprotection

James Downey and Michael Cohen

in Cardioprotection

Published on behalf of Oxford University Press

Published in print August 2009 | ISBN: 9780199544769
Published online May 2011 | e-ISBN: 9780191740107 | DOI:

Series: Oxford Cardiology Library

Endogenous Mechanisms of Cardioprotection

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Ischaemic preconditioning is the most powerful endogenous mechanism for limiting myocardial infarct size in the experimental setting. Its clinical application is limited to scenarios in which the index episode of ischaemia and reperfusion can be anticipated such as in the setting of cardiac surgery

Ischaemic postconditioning represents an endogenous cardioprotective strategy which is applied at the onset of myocardial reperfusion, thereby allowing its use as an adjunct to reperfusion in patients presenting with an acute myocardial infarction

Both ischaemic preconditioning and postconditioning recruit a common signal transduction pathway at the time of myocardial reperfusion, which can be targeted by pharmacological agents administered as adjuncts to reperfusion.

Chapter.  2889 words.  Illustrated.

Subjects: Cardiovascular Medicine

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