Pathophysiology in fibromyalgia syndrome

Ernest Choy

in Fibromyalgia Syndrome

Published on behalf of Oxford University Press

Published in print March 2009 | ISBN: 9780199547517
Published online May 2011 | e-ISBN: 9780199607259 | DOI:

Series: Oxford Rheumatology Library

Pathophysiology in fibromyalgia syndrome

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• Pain processing is complex and involves nociception, transmission, modulation, and perception. • Objective examination using function neuroimaging has demonstrated that pain in patients with fibromyalgia syndrome (FMS) is ‘real’. • Physiological pain is important in protecting us from harm, while maladaptive (pathologic) pain injury is caused by functional abnormality of the nervous system. FMS is characterized by maladaptive pain. • Sleep study in patients with FMS has confirmed reduced deep quality and increased wakefulness. In healthy volunteers, selective deprivation of non-REM sleep can induce symptoms and hyperalgesic tender sites of FMS. • Patients with FMS often report experiencing previous stressful or traumatic events. A reduced HPA axis response to stress can contribute to development or worsening of FMS.

Chapter.  3864 words.  Illustrated.

Subjects: Rheumatology

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