Chapter

Primary hyperaldosteronism

Sunil Nadar

in Hypertension

Published on behalf of Oxford University Press

ISBN: 9780199547579
Published online May 2011 | e-ISBN: 9780199607266 | DOI: http://dx.doi.org/10.1093/med/9780199547579.003.0004

Series: Oxford Cardiology Library

Primary hyperaldosteronism

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Primary hyperaldosteronism is an important treatable cause of hypertension. It is caused by aldosterone-producing tumors. Screening would be beneficial in patients with resistant hypertension and young hypertensive patients. Serum potassium alone as a screening test for primary hyperaldosteronism would miss nearly two-thirds of patients. Ratio of plasma aldosterone to plasma renin activity is accepted as the test of choice for screening. Imaging tests help localize the tumour. Surgical removal of tumour should be the first choice of treatment if feasible. Spironolactone is the drug of choice for medical therapy if surgery fails or is not possible.

Chapter.  2285 words.  Illustrated.

Subjects: Cardiovascular Medicine

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