Causes of Parkinson’s disease: genetics, environment and pathogenesis

Eng K. Tan and Heinz Reichmann

in Parkinson's Disease

Published on behalf of Oxford University Press

ISBN: 9780199550630
Published online May 2011 | e-ISBN: 9780199607297 | DOI:

Series: Oxford Neurology Library

Causes of Parkinson’s disease: genetics, environment and pathogenesis

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• Parkinson’s Disease (PD) is a neurodegenerative disorder of complex aetiology where both genetic and environmental factors play a role in its pathophysiology • A number of disease-causing genes have been identified in both familial and sporadic forms of PD, and some environmental factors have been shown to modulate the risk of the disease • Regardless of its underlying etiology, both in vitro and animal studies have suggested abnormalities in mitochondrial function, oxidative and nitrosative stress, accumulation of aberrant or misfolded proteins, and ubiquitin-proteasome system dysfunction represent the principal molecular pathways that underpin its pathophysiology.

Chapter.  3935 words.  Illustrated.

Subjects: Neurology

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