Chapter

Medical management of motor complications

D.A. Gallagher and Anthony H.V. Schapira

in Parkinson's Disease

Published on behalf of Oxford University Press

ISBN: 9780199550630
Published online May 2011 | e-ISBN: 9780199607297 | DOI: http://dx.doi.org/10.1093/med/9780199550630.003.0007

Series: Oxford Neurology Library

Medical management of motor complications

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• The development of levodopa-related motor complications is related to the dose and duration of levodopa use, the age of patient and severity of disease. • The initial use of dopamine agonists delays the onset of motor complications. • MAOB inhibitors, COMT inhibitors and dopamine agonists are all effective in treating wearing off. Modifications of levodopa use: increased dose or frequency may also be appropriate in some patients. • Amantadine is useful to reduce dyskinesias. Apomorphine or duodopa can be considered for selected patients. Surgery is beneficial for appropriate individuals.

Chapter.  3649 words. 

Subjects: Neurology

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