The management of erectile dysfunction

David E Price

in Diabetic Neuropathy

Published on behalf of Oxford University Press

ISBN: 9780199551064
Published online May 2011 | e-ISBN: 9780199607303 | DOI:

Series: Oxford Diabetes Library

The management of erectile dysfunction

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  • Endocrinology and Diabetes


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• Impotence is a distressing problem which affects 30%–40% of diabetic men. • Tumescence occurs as a result of nitric oxide (NO)-mediated smooth muscle relaxation of the erectile tissue leading to engorgement of the corpus cavernosum. • Erection is initiated by neuronal NO release and maintained by NO released by the local vascular endothelium. • Impotence in diabetes occurs as a result of endothelial dysfunction and autonomic neuropathy. • Phosphodiesterase 5 (PDE5) inhibitors are used for the first-line treatment of impotence in diabetes and are effective in 50% to 60% of diabetic men.

Chapter.  2355 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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