Research design

Janet L. Peacock and Philip J. Peacock

in Oxford Handbook of Medical Statistics

Published on behalf of Oxford University Press

ISBN: 9780199551286
Published online June 2011 | e-ISBN: 9780191726361 | DOI:

Series: Oxford Medical Handbooks

Research design

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Introduction - Introduction to research - Research questions - Interventional studies - Randomized controlled trials - Randomization in RCTs - Patient consent in research studies - Blinding in RCTs - RCTs: parallel groups and crossover designs - Zelen randomized consent design - Superiority and equivalence trials - Intention to treat analysis - Case–control studies - Cohort studies - Cross-sectional studies - Case study and series - Deducing causal effects - Designing an audit - Data collection in audit - Research versus audit - Data collection: sources of data - Data collection: outcomes - Outcomes: continuous and categorical - Collecting additional data - The study protocol - Sampling strategies - Choosing a sample size - Sample size for estimation studies: means - Sample size for estimation studies: proportions - Sample size for comparative studies - Sample size for comparative studies: means - Sample size for comparative studies: proportions - Sample size calculations: further issues - Sample size: other issues - Using a statistical program to do the calculations

Chapter.  19056 words.  Illustrated.

Subjects: Medical Statistics and Methodology

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