Chapter

Membranous nephropathy

Patrizia Passerini and Claudio Ponticelli

in Treatment of Primary Glomerulonephritis

Second edition

Published on behalf of Oxford University Press

Published in print May 2009 | ISBN: 9780199552887
Published online November 2012 | e-ISBN: 9780191753282 | DOI: http://dx.doi.org/10.1093/med/9780199552887.003.0007

Series: Oxford Clinical Nephrology Series

Membranous nephropathy

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Membranous nephropathy (MN) is a glomerular disease which is characterized histologically by uniform thickening of the glomerular capillary due to the presence of immunoglobulin-containing deposits on the outer or subepithelial aspect of the glomerular basement membrane (GBM). It exists in idiopathic (etiology unknown) or secondary (causally associated with another disorder) forms. Differentiation of the idiopathic membranous nephropathy (IMN) from secondary forms of MN may be difficult. It is a frequent cause of the nephrotic syndrome in adults. It is also characterized by a tendency for spontaneous remission in some patients and by persistence of proteinuria and slow progression to end-stage renal disease (ESRD) in others. Those patients with severe and un-remitting nephrotic syndrome may also suffer from disabling and even life-threatening extra-renal complications, such as thromboembolic events.

Chapter.  21179 words.  Illustrated.

Subjects: Nephrology

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