Immunoglobulin A nephropathy

Richard J. Glassock and Grace Lee

in Treatment of Primary Glomerulonephritis

Second edition

Published on behalf of Oxford University Press

Published in print May 2009 | ISBN: 9780199552887
Published online November 2012 | e-ISBN: 9780191753282 | DOI:

Series: Oxford Clinical Nephrology Series

Immunoglobulin A nephropathy

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The term immunoglobulin A nephropathy (IgA nephropathy or IgA N) refers to a primary glomerular disease characterized by the dominant or co-dominant, diffuse, and generalized mesangial deposition of IgA, often accompanied by deposition of IgG and the C3 component of complement in a similar distribution (Donadio and Grande, 2004; Barratt and Feehally, 2005; Tomino, 2007; Glassock, 2008; Lai, 2008). In the past, it has also been referred to as Berger's disease, to signify the senior author of the original publication describing the disorder that first appeared more than 4 decades ago in September of 1968 (Berger and Hinglais, 1968). IgA N is most likely the commonest primary glomerular disease in the developed world (D’Amico, 1987). The disease is characterized principally by episodic glomerular hematuria often with persistent proteinuria of a variable degree. It usually runs an indolent course, but may lead to end-stage renal disease (ESRD) in about 30–50% of cases after 25 years or more of follow-up.

Chapter.  25768 words.  Illustrated.

Subjects: Nephrology

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