Chapter

Membranoproliferative glomerulonephritis

Richard J. Glassock

in Treatment of Primary Glomerulonephritis

Second edition

Published on behalf of Oxford University Press

Published in print May 2009 | ISBN: 9780199552887
Published online November 2012 | e-ISBN: 9780191753282 | DOI: http://dx.doi.org/10.1093/med/9780199552887.003.0009

Series: Oxford Clinical Nephrology Series

Membranoproliferative glomerulonephritis

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Membranoproliferative glomerulonephritis (MPGN, also known as mesangiocapillary glomerulonephritis) is a designation given to a very heterogeneous collection of disorders that manifest by light microscopy both mesangial hyper-cellularity and proliferation accompanied by broadening of the peripheral capillary loops (Holley and Donadio, 1994; Glassock et al., 1995; Strife and West, 2001; Glassock, 2008) due to reduplication of the glomerular capillary basement membrane (known as ‘double-contour’). In many instances, these broadened capillary loops also display prominent interposition of cells between the layers of the basement membrane and/or subendothelial or intra-membranous electron-dense deposits that may be accompanied by fragmentation or distortion of the basement membrane itself. The disorders encompassed by this definition also frequently display persistent reduction in serum complement levels (West et al., 1965).

Chapter.  9222 words.  Illustrated.

Subjects: Nephrology

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