Microvascular complications

David Levy

in Type 1 Diabetes

Published on behalf of Oxford University Press

ISBN: 9780199553211
Published online September 2011 | e-ISBN: 9780191740190 | DOI:

Series: Oxford Diabetes Library

Microvascular complications

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• Hyperglycaemia damages the microvasculature through several mechanisms; strict control of hyperglycaemia remains overwhelmingly the most important factor in preventing and reversing microvascular complications in Type 1 diabetes. • End-stage microvascular complications (blindness, end-stage renal failure, amputations for neuropathic foot complications) are probably becoming less common; no single responsible factor can be identified. • The Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications follow-up (1982–2006) confirmed dramatic and long-lasting benefits of intensive therapy on microvascular complications (40–60% risk reduction) with A1C consistently maintained at ∼7% for ∼7 yrs.

Chapter.  10752 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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