Chapter

Macrovascular complications and lipids

David Levy

in Type 1 Diabetes

Published on behalf of Oxford University Press

ISBN: 9780199553211
Published online September 2011 | e-ISBN: 9780191740190 | DOI: http://dx.doi.org/10.1093/med/9780199553211.003.0006

Series: Oxford Diabetes Library

Macrovascular complications and lipids

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• Premature macrovascular disease, especially coronary artery disease, is common in Type 1 diabetes, even in the absence of albuminuria. • Stroke and peripheral vascular disease are also significantly more common. • Hyperglycaemia is the most important risk factor, and clinical macrovascular events and surrogates (coronary calcification and carotid intima–media thickness) were less severe in the previous intensively treated Diabetes Control and Complications Trial (DCCT) cohort studied in Epidemiology of Diabetes Interventions and Complications (EDIC). • In the absence of nephropathy, conventional lipid profiles in Type 1 patients are no different from those of non-diabetic individuals. • There is no convincing evidence base for the routine use of statin treatment or low-dose aspirin in younger patients without complications. • Insulin resistance, acquired through intensive insulin treatment and its associated weight gain, may contribute to macrovascular endpoints.

Chapter.  4803 words. 

Subjects: Endocrinology and Diabetes

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