Chapter

The pathogenesis of rheumatoid arthritis

Catherine Swales and Paul Wordsworth

Edited by Raashid Luqmani

in Rheumatoid Arthritis

Published on behalf of Oxford University Press

ISBN: 9780199556755
Published online May 2011 | e-ISBN: 9780199607334 | DOI: http://dx.doi.org/10.1093/med/9780199556755.003.0002

Series: Oxford Rheumatology Library

The pathogenesis of rheumatoid arthritis

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• Many cell types and mediators are implicated in the pathogenesis of rheumatoid arthritis • Tumour necrosis factor alpha (TNFα) is currently identified as one the most important cytokines responsible for mediating inflammation and damage in arthritis • Interleukin-17 (IL-17) has been found to regulate many cytokines including TNFα • T helper 17 (TH17) and T helper 1 (TH1) cells are the dominant T cell subsets in rheumatoid synovium • Novel mechanisms for perpetuation of arthritis are being elucidated, which may lead to more effective therapeutic strategies in future.

Chapter.  2883 words.  Illustrated.

Subjects: Rheumatology

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