Chapter

New aspects of normal bone biology

Susan M. Ott

in The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Second edition

Published on behalf of Oxford University Press

Published in print June 2010 | ISBN: 9780199559176
Published online November 2012 | e-ISBN: 9780191753350 | DOI: http://dx.doi.org/10.1093/med/9780199559176.003.002

Series: Oxford Clinical Nephrology Series

New aspects of normal bone biology

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Bone as a structural material must be strong enough to support the body weight and light enough for efficient movement. Some of the most important new developments in bone biology help explain the mechanisms of sensing and responding to mechanical loading. New genetic approaches combined with clinical observations have led to discoveries of signaling pathways that may eventually lead to new therapies to treat or prevent bone diseases. This chapter will focus on some recently defined factors that influence bone remodeling, with an emphasis on those that could potentially be modified to improve the bone strength.

Chapter.  5998 words.  Illustrated.

Subjects: Rheumatology ; Nephrology

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