Chapter

Regulation of parathyroid hormone biosynthesis and gene expression

Tally Naveh-Many and Justin Silver

in The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Second edition

Published on behalf of Oxford University Press

Published in print June 2010 | ISBN: 9780199559176
Published online November 2012 | e-ISBN: 9780191753350 | DOI: http://dx.doi.org/10.1093/med/9780199559176.003.005

Series: Oxford Clinical Nephrology Series

Regulation of parathyroid hormone biosynthesis and gene expression

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Parathyroid hormone (PTH) is at the centre of the intricate hormonal and cellular responses to changes in mineral metabolism. The parathyroid senses small changes in serum calcium to alter PTH secretion, which then binds to its receptor in its target tissues, the bone, and kidney to correct serum calcium. The parathyroid responds to changes in calcium, phosphate (Pi), 1,25(OH)2 vitamin D (1,25D), and fibroblast growth factor 23 (FGF23). Parathyroid cells have few secretory granules as compared with other endocrine cells and, therefore, PTH production is regulated largely at the levels of PTH gene expression and parathyroid cell proliferation. In this chapter we discuss the mechanisms of how 1,25D, calcium, Pi, and FGF23 regulate PTH gene expression.

Chapter.  6519 words.  Illustrated.

Subjects: Rheumatology ; Nephrology

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