Chapter

Abnormal parathyroid gland function in CKD

Ewa Lewin and Mariano Rodriguez

in The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Second edition

Published on behalf of Oxford University Press

Published in print June 2010 | ISBN: 9780199559176
Published online November 2012 | e-ISBN: 9780191753350 | DOI: http://dx.doi.org/10.1093/med/9780199559176.003.006

Series: Oxford Clinical Nephrology Series

Abnormal parathyroid gland function in CKD

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The abnormal function of the parathyroid glands in CKD is resulting in increased PTH biosynthesis and secretion and parathyroid cell hyperplasia. At the molecular level development of 2HPT is related to changes in CaR and VDR signaling and disturbances in the regulation of PTH mRNA. Other factors of importance for the regulation of parathyroid function and cell proliferation include some of autocrine or paracrine nature. The expression of all these factors is influenced by CKD. As such, hyperparathyroidism associated with chronic uremia results from a combination of functional and structural changes in the parathyroid glands.

Chapter.  13470 words.  Illustrated.

Subjects: Rheumatology ; Nephrology

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