Growth factors and cytokines in renal bone disease

Esther A. González and Kevin J. Martin

in The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Second edition

Published on behalf of Oxford University Press

Published in print June 2010 | ISBN: 9780199559176
Published online November 2012 | e-ISBN: 9780191753350 | DOI:

Series: Oxford Clinical Nephrology Series

Growth factors and cytokines in renal bone disease

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In summary, in addition to the effects of the well known calciotropic hormones, normal bone remodeling appears to depend on the integrated effects of a variety of growth factors and cytokine systems. There are many abnormalities in the setting of chronic kidney disease, not only in circulating hormones, but also in terms of systemic inflammatory responses associated with abnormalities in a variety of cytokines. Since these cytokines appear to impact upon the bone remodeling cycle, they are likely to modify the active cellular processes of bone, and thus alter the manifestations of renal osteodystrophy. Further work is required to specifically delineate their actions on bone, especially in the setting of renal bone disease and to investigate the potential of modifying these cytokine and growth factor pathways with specific therapeutic agents to improve not only the abnormalities of the skeleton, but which might also have the potential to influence calcifications at extraskeletal sites.

Chapter.  2965 words.  Illustrated.

Subjects: Rheumatology ; Nephrology

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