Chapter

Dialysis-associated amyloidosis

T. Bardin

in The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Second edition

Published on behalf of Oxford University Press

Published in print June 2010 | ISBN: 9780199559176
Published online November 2012 | e-ISBN: 9780191753350 | DOI: http://dx.doi.org/10.1093/med/9780199559176.003.016

Series: Oxford Clinical Nephrology Series

Dialysis-associated amyloidosis

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In 1978, Kenzora reported for the first time the identification of amyloid deposition in a carpal tunnel biopsy specimen from a patient undergoing hemodialysis. From this time, dialysis-associated amyloidosis has been recognized as an increasingly significant problem in renal failure patients maintained on long-term dialysis therapies. Deposits involve mainly articular and peri-articular tissues resulting in a disabling arthropathy, the frequency of which increases with length of survival upon dialysis. Amyloid arthropathy is at present considered as one of the main factors limiting the quality of life of long-term survivors. Moreover, systemic deposition and neurological compromise following destructive involvement of spine are rare, but life-threatening complications. This review will attempt to picture the features of the disease and to differentiate them from articular symptoms of other etiologies in dialysis patients.

Chapter.  6689 words. 

Subjects: Rheumatology ; Nephrology

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