Chapter

The role of the skeleton in the pathogenesis of vascular calcification in the chronic kidney disease–mineral bone disorder

Keith A. Hruska, Suresh Mathew, Yifu Fang, Imran Memon and T. Keefe Davis

in The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease

Second edition

Published on behalf of Oxford University Press

Published in print June 2010 | ISBN: 9780199559176
Published online November 2012 | e-ISBN: 9780191753350 | DOI: http://dx.doi.org/10.1093/med/9780199559176.003.020

Series: Oxford Clinical Nephrology Series

The role of the skeleton in the pathogenesis of vascular calcification in the chronic kidney disease–mineral bone disorder

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Considerable scientific progress in the pathogenesis of vascular calcification accrued in recent years will be reviewed in this chapter with a focus on the role of the skeleton. Factors regulating mesenchymal cell differentiation and their role in the neo-intimal calcification of atherosclerosis, and the vascular media calcification observed in CKD and diabetes will be discussed, as will the role of bone regulatory proteins in bone mineralization and vascular calcification. This will include recent studies related to the discovery of new skeletal hormones involved in regulating phosphate homeostasis, sensing skeletal hydroxyapatite precipitation, regulating calcitriol production, regulating energy production and utilization, and affecting vascular calcification. Finally, the relationship between skeletal mineralization and vascular mineralization will be discussed in terms of their links, especially through the regulation of bone formation and serum phosphate concentrations.

Chapter.  6338 words.  Illustrated.

Subjects: Rheumatology ; Nephrology

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